Diethyl Malonate → Diethyl 2-(5-bromopyridin-2-yl)malonate

HRID 213975

Reaction equation

HRID 213975 reaction equation
[Br:16][c:17]1[cH:18][cH:19][c:20]([I:23])[n:21][cH:22]1.[Br:1][c:2]1[cH:3][cH:4][c:5]([CH:6]([CH2:7][CH2:8][CH2:9][Cl:10])[C:11]([OH:12])=[O:13])[n:14][cH:15]1.[CH2:24]([CH3:25])[O:26][C:27]([CH2:28][C:29](=[O:30])[O:31][CH2:32][CH3:33])=[O:34]>>[Br:16][c:17]1[cH:18][cH:19][c:20]([CH:28]([C:27]([O:26][CH2:24][CH3:25])=[O:34])[C:29](=[O:30])[O:31][CH2:32][CH3:33])[n:21][cH:22]1

Participants

4

Reactant 3

HCID 7761Diethyl MalonateHCID 5936905-Bromo-2-iodopyridineHCID 592382662-(5-Bromo-pyridin-2-yl)-5-chloro-pentanoic acid

Product 1

HCID 59238270Diethyl 2-(5-bromopyridin-2-yl)malonate

Sources & evidence

ORD record
ord-16bf40a098b946dd844e700b12230803
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Linked notes

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