Hydrochloric Acid → 3-Chloro-2,6-difluoroaniline

Reaction equation

[CH3:19][OH:20].[Cl:1][c:2]1[c:3]([F:17])[c:4]([NH:9][C:10](=[O:11])[O:12][C:13]([CH3:14])([CH3:15])[CH3:16])[c:5]([F:8])[cH:6][cH:7]1.[ClH:18].[O:21]1[CH2:22][CH2:23][O:24][CH2:25][CH2:26]1>>[Cl:1][c:2]1[c:3]([F:17])[c:4]([NH2:9])[c:5]([F:8])[cH:6][cH:7]1

Participants

Reactant 4

HCID 313Hydrochloric Acid

HCID 887Methanol

HCID 312751,4-Dioxane

HCID 86083514tert-Butyl (3-chloro-2,6-difluorophenyl)carbamate

Product 1

HCID 177507453-Chloro-2,6-difluoroaniline

Sources & evidence

ORD record: ord-3eb65a51c7e7418fa7513b771cb6d6fa
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (4/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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