Acetate → 6-Iodo-4-methylpyridin-3-amine

Reaction equation

[C:23]([O-:24])(=[O:25])[CH3:26].[C:28]([O-:29])(=[O:30])[CH3:31].[CH3:15][CH2:16][O:17][CH2:18][CH3:19].[Cl:20][CH2:21][Cl:22].[ClH:14].[I:1][c:2]1[n:3][cH:4][c:5]([N+:9]([O-:10])=[O:11])[c:6]([CH3:8])[cH:7]1.[Na+:13].[OH-:12].[Pd+2:27]>>[I:1][c:2]1[n:3][cH:4][c:5]([NH2:9])[c:6]([CH3:8])[cH:7]1

Participants

Reactant 8

HCID 175Acetate2×

HCID 313Hydrochloric Acid

HCID 923Sodium Ion

HCID 961Hydroxide

HCID 3283Diethyl Ether

HCID 6344Dichloromethane

HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)

HCID 230701672-Iodo-4-methyl-5-nitropyridine

Product 1

HCID 230701206-Iodo-4-methylpyridin-3-amine

Sources & evidence

ORD record: ord-96e15d7b872d4612ba09c060104a51fa
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (4/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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