(1S,2R)-(+)-Norephedrine → 1-phenyl-1-(1-propan-2-ylindazol-5-yl)oxypropan-2-amine

HRID 2150498Notes

Reaction equation

HRID 2150498 reaction equation
[C:25](=[O:26])([O-:27])[O-:28].[CH3:31][CH2:32][CH2:33][C:34]#[N:35].[Cs+:29].[Cs+:30].[Cu:36][I:37].[I:1][c:2]1[cH:3][c:4]2[cH:5][n:6][n:7]([CH:11]([CH3:12])[CH3:13])[c:8]2[cH:9][cH:10]1.[NH2:14][CH:15]([CH:16]([OH:17])[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)[CH3:24]>>[c:2]1([O:17][CH:16]([CH:15]([NH2:14])[CH3:24])[c:18]2[cH:19][cH:20][cH:21][cH:22][cH:23]2)[cH:3][c:4]2[cH:5][n:6][n:7]([CH:11]([CH3:12])[CH3:13])[c:8]2[cH:9][cH:10]1

Participants

7

Reactant 6

HCID 4786(1S,2R)-(+)-NorephedrineHCID 8008ButyronitrileHCID 19660Carbonate IonHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 104967Cesium cation2×HCID 593398645-iodo-1-isopropyl-1H-indazole

Product 1

HCID 1784647181-phenyl-1-(1-propan-2-ylindazol-5-yl)oxypropan-2-amine

Sources & evidence

ORD record
ord-73b279413782431d9373a7a666141a66
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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