Water → N-Cyclopropylmethyl-2-ethyl-7-iodo-N-(tetrahydro-2H-pyran-4-ylmethyl)pyrazolo[1,5-a]pyridine-3-amine

HRID 2154070

Reaction equation

HRID 2154070 reaction equation
[CH2:24]([Li:25])[CH2:26][CH2:27][CH3:28].[CH3:52][CH2:53][CH2:54][CH2:55][CH2:56][CH2:57][CH3:58].[CH:1]1([CH2:4][N:5]([CH2:6][CH:7]2[CH2:8][CH2:9][O:10][CH2:11][CH2:12]2)[c:13]2[c:14]([CH2:22][CH3:23])[n:15][n:16]3[c:17]2[cH:18][cH:19][cH:20][cH:21]3)[CH2:2][CH2:3]1.[F:29][c:30]1[c:31]([I:36])[c:32]([F:33])[c:34]([F:35])[c:37]([F:38])[c:39]1[F:40].[O:41]1[CH2:42][CH2:43][CH2:44][CH2:45]1.[O:47]1[CH2:48][CH2:49][CH2:50][CH2:51]1.[OH2:46].[OH2:59]>>[CH:1]1([CH2:4][N:5]([CH2:6][CH:7]2[CH2:8][CH2:9][O:10][CH2:11][CH2:12]2)[c:13]2[c:14]([CH2:22][CH3:23])[n:15][n:16]3[c:17]2[cH:18][cH:19][cH:20][c:21]3[I:36])[CH2:2][CH2:3]1

Participants

7

Reactant 6

HCID 962Water2×HCID 8028Tetrahydrofuran2×HCID 8900HeptaneHCID 70008PentafluoroiodobenzeneHCID 58801672N-Cyclopropylmethyl-N-(2-ethylpyrazolo[1,5-a]pyridin-3-yl)-N-tetrahydro-2H-4-pyranylmethylamineHCID 178418339Butyllithium

Product 1

HCID 11339625N-Cyclopropylmethyl-2-ethyl-7-iodo-N-(tetrahydro-2H-pyran-4-ylmethyl)pyrazolo[1,5-a]pyridine-3-amine

Sources & evidence

ORD record
ord-afb6eaa4991b431b911d11aed34e2b54
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Linked notes

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