Hydrochloric Acid → 1-(4-Chloro-3-methoxyphenyl)piperidin-4-one

Reaction equation

[Cl:1][c:2]1[c:3]([O:18][CH3:19])[cH:4][c:5]([N:8]2[CH2:9][CH2:10][C:11]3([O:12][CH2:15][CH2:14][O:13]3)[CH2:16][CH2:17]2)[cH:6][cH:7]1.[ClH:20].[Na+:22].[OH-:21]>>[Cl:1][c:2]1[c:3]([O:18][CH3:19])[cH:4][c:5]([N:8]2[CH2:9][CH2:10][C:11](=[O:12])[CH2:16][CH2:17]2)[cH:6][cH:7]1

Participants

Reactant 4

HCID 313Hydrochloric Acid

HCID 923Sodium Ion

HCID 961Hydroxide

HCID 685538928-(4-Chloro-3-methoxyphenyl)-1,4-dioxa-8-azaspiro[4.5]decane

Product 1

HCID 685574401-(4-Chloro-3-methoxyphenyl)piperidin-4-one

Sources & evidence

ORD record: ord-067fb4c5f78b4c5eb2038eb911692857
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (4/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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