Dimethylamine → 5-Chloro-N,N,2-trimethyl-6-phenyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine

Reaction equation

[CH3:19][NH:20][CH3:21].[Cl:1][c:2]1[n:3][c:4]2[n:5]([c:6]([Cl:14])[c:7]1-[c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)[n:15][c:16]([CH3:18])[n:17]2.[Cl:28][CH2:29][Cl:30].[O:22]=[CH:23][N:24]([CH3:25])[CH3:26].[OH2:27]>>[Cl:1][c:2]1[n:3][c:4]2[n:5]([c:6]([N:20]([CH3:19])[CH3:21])[c:7]1-[c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)[n:15][c:16]([CH3:18])[n:17]2

Participants

Reactant 5

HCID 674Dimethylamine

HCID 962Water

HCID 6228Dimethylformamide

HCID 6344Dichloromethane

HCID 866306805,7-Dichloro-2-methyl-6-phenyl[1,2,4]triazolo[1,5-a]pyrimidine

Product 1

HCID 866306975-Chloro-N,N,2-trimethyl-6-phenyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine

Sources & evidence

ORD record: ord-7174474ca31f4f1baa473c1c929fd5ba
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (4/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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