Sodium ion → N-[3-({2-[(N,N-dimethylglycyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide

HRID 2158031

Reaction equation

HRID 2158031 reaction equation
[CH3:25][n:26]1[n:27][c:28]([CH3:34])[cH:29][c:30]1[C:31](=[O:32])[Cl:33].[CH3:35][N:36]1[CH2:37][CH2:38][CH2:39][C:40]1=[O:41].[NH2:1][c:2]1[cH:3][c:4]([O:5][c:6]2[cH:7][cH:8][c:9]3[n:10]([n:11]2)[cH:12][c:13]([NH:15][C:16]([CH2:17][N:18]([CH3:19])[CH3:20])=[O:21])[n:14]3)[cH:22][cH:23][cH:24]1.[Na+:43].[OH-:42]>>[NH:1]([c:2]1[cH:3][c:4]([O:5][c:6]2[cH:7][cH:8][c:9]3[n:10]([n:11]2)[cH:12][c:13]([NH:15][C:16]([CH2:17][N:18]([CH3:19])[CH3:20])=[O:21])[n:14]3)[cH:22][cH:23][cH:24]1)[C:31]([c:30]1[n:26]([CH3:25])[n:27][c:28]([CH3:34])[cH:29]1)=[O:32]

Participants

6

Reactant 5

HCID 923Sodium ionHCID 961HydroxideHCID 13387N-methyl-2-pyrrolidoneHCID 27362992,5-Dimethyl-2H-pyrazole-3-carbonyl chlorideHCID 57708553N-[6-(3-aminophenoxy)imidazo[1,2-b]pyridazin-2-yl]-N2,N2-dimethylglycinamide

Product 1

HCID 24767980N-[3-({2-[(N,N-dimethylglycyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide

Sources & evidence

ORD record
ord-847d7e6e7e9f46f3aa8458f62638bacb
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Linked notes

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