Hydrochloric Acid → 4-(3-(Trifluoromethyl)phenyl)-1,2,3,6-tetrahydropyridine hydrochloride

HRID 215825

Reaction equation

HRID 215825 reaction equation
[F:1][C:2]([F:17])([F:16])[C:3]1[CH:4]=[C:5]([C:9]2(O)[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[CH:6]=[CH:7][CH:8]=1.[ClH:18]>O>[ClH:18].[F:17][C:2]([F:1])([F:16])[C:3]1[CH:4]=[C:5]([C:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH:10]=2)[CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 752554-[3-(Trifluoromethyl)phenyl]-4-piperidinol

Product 1

HCID 234359914-(3-(Trifluoromethyl)phenyl)-1,2,3,6-tetrahydropyridine hydrochloride

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

In a round-bottomed flask equipped with a mechanical stirrer, 50 g of 4-(3-trifluoromethylphenyl)-4-piperidinol are charged to 377 ml of water and 514 ml of concentrated hydrochloric acid. The mixture is left to react at reflux for 5 hours and is then cooled to ambient temperature. A white solid precipitates. It is filtered off through a Büchner funnel and dried in an oven. 37 g of a white solid are isolated. M.p. 203-204° C.

Workup

  1. customIn a round-bottomed flask equipped with a mechanical stirrer
  2. waitThe mixture is left
  3. customto react
  4. temperatureat reflux for 5 hours
  5. customA white solid precipitates
  6. filtrationIt is filtered off through a Büchner funnel
  7. customdried in an oven

Sources & evidence

ORD record
ord-8d33625c1f5646a4be3f592063add37e
Source dataset
uspto-grants-2012_06
Patent number
US08193190B2

Linked notes

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