Tetrahydrofuran → 2-(4-Cyclopentylamino-phenyl)-1,1,1-trifluoro-4-phenyl-but-3-yn-2-ol
Reaction equation
[CH2:32]1[O:33][CH2:34][CH2:35][CH2:36]1.[CH2:9]([Li:10])[CH2:11][CH2:12][CH3:13].[CH:14]1([NH:19][c:20]2[cH:21][cH:22][c:23]([C:26]([C:27]([F:28])([F:29])[F:30])=[O:31])[cH:24][cH:25]2)[CH2:15][CH2:16][CH2:17][CH2:18]1.[c:1]1([C:7]#[CH:8])[cH:2][cH:3][cH:4][cH:5][cH:6]1>>[c:1]1([C:7]#[C:8][C:26]([c:23]2[cH:22][cH:21][c:20]([NH:19][CH:14]3[CH2:15][CH2:16][CH2:17][CH2:18]3)[cH:25][cH:24]2)([C:27]([F:28])([F:29])[F:30])[OH:31])[cH:2][cH:3][cH:4][cH:5][cH:6]1Participants
5
Sources & evidence
- ORD record
- ord-98d4c2b168014a5bb2a019f6177a5a2b
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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