(+-)-2-Butanol → 4-(6-Oxo-1,6-dihydro-pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester

HRID 2160448

Reaction equation

HRID 2160448 reaction equation
[C:18](=[O:19])([O:20][C:21]([CH3:22])([CH3:23])[CH3:24])[N:25]1[CH2:26][CH2:27][NH:28][CH2:29][CH2:30]1.[CH2:9]([N:10]([CH:11]([CH3:12])[CH3:13])[CH:14]([CH3:15])[CH3:16])[CH3:17].[CH:31]([OH:32])([CH2:33][CH3:34])[CH3:35].[Cl:1][c:2]1[cH:3][c:4](=[O:8])[nH:5][cH:6][n:7]1>>[c:2]1([N:28]2[CH2:27][CH2:26][N:25]([C:18](=[O:19])[O:20][C:21]([CH3:22])([CH3:23])[CH3:24])[CH2:30][CH2:29]2)[cH:3][c:4](=[O:8])[nH:5][cH:6][n:7]1

Participants

5

Reactant 4

HCID 6568(+-)-2-ButanolHCID 81531DiisopropylethylamineHCID 143452tert-Butyl piperazine-1-carboxylateHCID 1354454786-Chloropyrimidin-4-ol

Product 1

HCID 1361025614-(6-Oxo-1,6-dihydro-pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-c64d87d9ac5e41eebb922247c1eafbb6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Linked notes

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