Hydrochloric Acid → Ethyl 2-methoxyethanecarboximidate hydrochloride

Temperature

-10 °C

Hydrochloric acid gas is bubbled through a solution of methoxyacetonitrile (26 g, 0.37 mol) in EtOH (22 mL) and diethyl ether (118 mL), which is chilled to −10° C. for twenty minutes. The reaction vessel is capped and stirred for 17 hours at ambient temperature. The mixture is cooled to −10° C. The solid that forms is collected by filtration, washed with diethyl ether and air dried to afford 2-methoxy-acetimidic acid ethyl ester hydrochloride (49.3 g, 87%) as a solid.

1. customThe reaction vessel is capped
2. temperatureThe mixture is cooled to −10° C
3. filtrationThe solid that forms is collected by filtration
4. washwashed with diethyl ether and air
5. customdried

ORD record

ord-374557f2bc98456dbbed958ff9f54c3d

Source dataset

uspto-grants-2012_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08193183B2