Water → 5-t-Butyl-3-cyclobutanecarbonylaminopyrazole

HRID 2164503Notes

Reaction equation

HRID 2164503 reaction equation
[NH2:1][C:2]1[CH:6]=[C:5]([C:7]([CH3:10])([CH3:9])[CH3:8])[NH:4][N:3]=1.C(N(CC)CC)C.[CH:18]1([C:22](Cl)=[O:23])[CH2:21][CH2:20][CH2:19]1.O>C(Cl)Cl.C(Cl)(Cl)(Cl)Cl>[C:7]([C:5]1[NH:4][N:3]=[C:2]([NH:1][C:22]([CH:18]2[CH2:21][CH2:20][CH2:19]2)=[O:23])[CH:6]=1)([CH3:10])([CH3:9])[CH3:8]

Participants

7

Reactant 4

HCID 962WaterHCID 8471TriethylamineHCID 78705Cyclobutanecarbonyl chlorideHCID 5227873-Amino-5-tert-butylpyrazole

Product 1

HCID 134770005-t-Butyl-3-cyclobutanecarbonylaminopyrazole

Reagents, catalysts & solvents 2

HCID 5943Carbon TetrachlorideSolventHCID 6344DichloromethaneSolvent

Procedure

4.3 g (0.03 mole) of 3-amino-5-t-butylpyrazole as prepared in Example 1 and 3 g of triethylamine were dissolved in 30 ml of methylene chloride. To this solution was added dropwise 3.6 g of cyclobutanecarboxylic acid chloride dissolved in 30 ml of carbon tetrachloride. The resulting mixture was allowed to stand at room temperature over night. Thereafter, water was added thereto followed by shaking it. Crystals thus formed were collected by filtration and washed with water and carbon tetrachloride to obtain 5-t-butyl-3-cyclobutanecarbonylaminopyrazole.

Workup

  1. waitto stand at room temperature over night
  2. customCrystals thus formed
  3. filtrationwere collected by filtration
  4. washwashed with water and carbon tetrachloride

Sources & evidence

ORD record
ord-7b86865510af4e1e9851b0c31e5ea268
Source dataset
uspto-grants-1985_03
Patent number
US04505739

Reaction notes

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