Sodium Cyanide → 2-Amino-3-(5-methoxy-3-indolyl)-propionitrile
Reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH:7]=[C:6]2[CH2:12][C:13]#[N:14].[C-:15]#[N:16].[Na+]>CN(C)C=O>[NH2:14][CH:13]([CH2:12][C:6]1[C:5]2[C:9](=[CH:10][CH:11]=[C:3]([O:2][CH3:1])[CH:4]=2)[NH:8][CH:7]=1)[C:15]#[N:16]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Using the same method starting from 5.4 millimoles (1 g) of (5-methoxy-3-indolyl)-acetonitrile and replacing of cyanising agent by 20 ml of a normal solution of sodium cyanide in dimethylformamide, there are obtained, after purification by an acid-base extraction, 0.50 g of 2-amino-3-(5-methoxy-3-indolyl)-propionitrile with a yield of 43%.
Workup
- customare obtained
- customafter purification
- extractionby an acid-base extraction, 0.50 g of 2-amino-3-(5-methoxy-3-indolyl)-propionitrile with a yield of 43%
Sources & evidence
- ORD record
- ord-3cd9ff2b357c4ef9b1b83b9fe51cc901
- Source dataset
- uspto-grants-1990_07
- Patent number
- US04942221
Reaction notes
Loading…