2-Chloro-5-methylphenol → (S)-Methyl 2-(2-chloro-5-methylphenoxy)butanoate

Reaction equation

[OH:1][C@H:2]([CH2:7][CH3:8])[C:3]([O:5][CH3:6])=[O:4].[Cl:9][C:10]1[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][C:11]=1O>>[Cl:9][C:10]1[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][C:11]=1[O:1][C@@H:2]([CH2:7][CH3:8])[C:3]([O:5][CH3:6])=[O:4]

Participants

Reactant 2

HCID 120082-Chloro-5-methylphenol

HCID 11701033(R)-Methyl 2-hydroxybutanoate

Product 1

HCID 71075856(S)-Methyl 2-(2-chloro-5-methylphenoxy)butanoate

Procedure

The title compound was prepared following the same protocol as described in Step 1, Example 42, using the (R)-methyl 2-hydroxybutanoate instead of the (S)-methyl 2-hydroxypropanoate and the 2-chloro-5-methylphenol instead of the m-cresol.

Sources & evidence

ORD record: ord-e869e4bd2bfa4e61b641bf85a3948371
Source dataset: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09051265B2

Reaction notes

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