Ethyl Acetate → 6-Nitro-2-(2,3-dihydro-1,4-benzodioxine-6-yl)-quinazoline
Reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[N:10]=[C:9]([C:14]1[CH:19]=[CH:18][C:17]3[O:20][CH2:21][O:22][C:16]=3[CH:15]=1)[N:8]=[CH:7]2)([O-:3])=[O:2].[CH3:23]COC(C)=O>>[N+:1]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[N:10]=[C:9]([C:14]1[CH:19]=[CH:18][C:17]3[O:20][CH2:21][CH2:23][O:22][C:16]=3[CH:15]=1)[N:8]=[CH:7]2)([O-:3])=[O:2]Participants
3
Procedure
This compound was synthesized in 70% yield, according to the procedure described in example 3 for 6-nitro-2-(3,4-methylendioxy-phenyl)-quinazoline. C16H11N3O4, MW: 309.28; mp: 263-265; TLC (tol/AcOEt 7/3) Rf=0.80.
Workup
- customThis compound was synthesized in 70% yield
Sources & evidence
- ORD record
- ord-68a2b86c0b4b463c8791861249cecab1