Tert-butyl (1-oxo-1,3-dihydro-2-benzofuran-5-yl)acetate → (1-Oxo-1,3-dihydro-2-benzofuran-5-yl)acetic acid
Reaction equation
[O:1]=[C:2]1[C:6]2[CH:7]=[CH:8][C:9]([CH2:11][C:12]([O:14]C(C)(C)C)=[O:13])=[CH:10][C:5]=2[CH2:4][O:3]1>C(O)(C(F)(F)F)=O>[O:1]=[C:2]1[C:6]2[CH:7]=[CH:8][C:9]([CH2:11][C:12]([OH:14])=[O:13])=[CH:10][C:5]=2[CH2:4][O:3]1Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
tert-Butyl (1-oxo-1,3-dihydro-2-benzofuran-5-yl)acetate (1.2 g, 4.8 mmol) was dissolved in TFA and stirred at room temperature for one h. The reaction mixture was concentrated and pumped under vacuum overnight to afford the title compound. LC-MS (IE, m/z): 193.2 [M+1]+.
Workup
- concentrationThe reaction mixture was concentrated
- custompumped under vacuum overnight
Sources & evidence
- ORD record
- ord-c62a8fe2907d4f8b86e5442bd5f96207
- Source dataset
- uspto-grants-2015_06
- Patent number
- US09056859B2
Reaction notes
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