Hydrochloric Acid → HCID 86712400, compound

Reaction equation

C([O:3][C:4](=[O:26])[C:5]([C:8]1[C:13]([O:14][C:15]2[CH:16]=[N:17][C:18]3[C:23]([CH:24]=2)=[CH:22][CH:21]=[CH:20][C:19]=3[F:25])=[CH:12][CH:11]=[CH:10][N:9]=1)([CH3:7])[CH3:6])C.[OH-].[Na+].Cl>C(O)C>[F:25][C:19]1[CH:20]=[CH:21][CH:22]=[C:23]2[C:18]=1[N:17]=[CH:16][C:15]([O:14][C:13]1[C:8]([C:5]([CH3:7])([CH3:6])[C:4]([OH:26])=[O:3])=[N:9][CH:10]=[CH:11][CH:12]=1)=[CH:24]2

Participants

Procedure

0.33 g of 2-[3-(8-fluoro-quinolin-3-yloxy)-pyridin-2-yl]-2-methylpropionic acid ethyl ester were dissolved in 1 ml of ethanol. 2 ml of 4N aqueous sodium hydroxide solution were added thereto followed by heating to reflux for 48 hours. Subsequently, dilute hydrochloric acid was added thereto followed by extracting with ethyl acetate and distilling off the solvent of the organic layer to obtain 0.25 g of 2-[3-(8-fluoro-quinolin-3-yloxy)-pyridin-2-yl]-2-methylpropionic acid.