Trifluoroacetic acid → (1S,6R)-3,8-diazabicyclo[4.2.0]octan-8-yl(3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone
Reaction equation
[F:1][C:2]1[C:3]([N:25]2[N:29]=[CH:28][CH:27]=[N:26]2)=[C:4]([CH:22]=[CH:23][CH:24]=1)[C:5]([N:7]1[C@H:14]2[C@H:9]([CH2:10][CH2:11][N:12](C(OC(C)(C)C)=O)[CH2:13]2)[CH2:8]1)=[O:6].C(O)(C(F)(F)F)=O>C(Cl)Cl>[C@H:14]12[N:7]([C:5]([C:4]3[CH:22]=[CH:23][CH:24]=[C:2]([F:1])[C:3]=3[N:25]3[N:29]=[CH:28][CH:27]=[N:26]3)=[O:6])[CH2:8][C@H:9]1[CH2:10][CH2:11][NH:12][CH2:13]2Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To (1S,6R)-tert-butyl 8-(3-fluoro-2-(2H-1,2,3-triazol-2-yl)benzoyl)-3,8-diazabicyclo[4.2.0]octane-3-carboxylate (656 mg, 1.6 mmol) in CH2Cl2 (10 mL) was added TFA (10 mL). After 3 h, the volatiles were removed via rotovap. The resulting residue was neutralized using 5% Na2CO3 (aq) and extracted with CH2Cl2 (3×). The aqueous layer was saturated with NaCl and extracted with CH2Cl2 (3×). The combined organics were dried (Na2SO4) and concentrated to give the title compound as a yellow foam that was used without further purification. MS (ESI) mass calcd. C15H16FN5O, 301.32; m/z found 302.0 [M+H]+.