2,6-Dibromopyridine → tert-Butyl 4-(6-bromopyridin-2-yl)-1,4-diazepane-1-carboxylate

HRID 2175123Notes

Reaction equation

HRID 2175123 reaction equation
Br[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Br:8])[N:3]=1.[C:9]([O:13][C:14](=[O:23])[NH:15][CH:16]1C[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1)([CH3:12])([CH3:11])[CH3:10]>>[C:9]([O:13][C:14]([N:15]1[CH2:16][CH2:17][CH2:18][N:19]([C:2]2[CH:7]=[CH:6][CH:5]=[C:4]([Br:8])[N:3]=2)[CH2:20][CH2:21]1)=[O:23])([CH3:10])([CH3:11])[CH3:12]

Participants

3

Reactant 2

HCID 122742,6-DibromopyridineHCID 4645994tert-butyl N-(azepan-4-yl)carbamate

Product 1

HCID 70700340tert-Butyl 4-(6-bromopyridin-2-yl)-1,4-diazepane-1-carboxylate

Procedure

The preparation is carried out analogously starting from 1.02 g (4.31 mmol) of 2,6-dibromopyridine and 856 mg (4.27 mmol) of azepan-4-ylcarbamic acid tert-butyl ester.

Sources & evidence

ORD record
ord-bfa14ed4aa0b4d43a7e736d063f479db
Source dataset
uspto-grants-2015_06
Patent number
US09062015B2

Reaction notes

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