(S)-1-[3-(4-Methoxy-benzyl)-5-(2,2,2-trifluoro-ethoxy)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl]-pyrrolidin-3-ol → HCID 178521640, compound
Reaction equation
COC1C=CC(C[N:8]2[C:12]3[N:13]=[C:14]([O:23][CH2:24][C:25]([F:28])([F:27])[F:26])[N:15]=[C:16]([N:17]4[CH2:21][CH2:20][C@H:19]([OH:22])[CH2:18]4)[C:11]=3[N:10]=[N:9]2)=CC=1>C(O)(C(F)(F)F)=O>[F:27][C:25]([F:26])([F:28])[CH2:24][O:23][C:14]1[N:15]=[C:16]([N:17]2[CH2:21][CH2:20][C@H:19]([OH:22])[CH2:18]2)[C:11]2[N:10]=[N:9][NH:8][C:12]=2[N:13]=1Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
(S)-1-[3-(4-Methoxy-benzyl)-5-(2,2,2-trifluoro-ethoxy)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl]-pyrrolidin-3-ol (example 109, d) in 4.57 mL TFA was heated to 80° C. over night and evaporated. The residue was treated with 1M NaOH and washed with EtOAc. The combined organic layer was evaporated to yield the crude title compound which was used in the consecutive step without further purification. MS (m/e): 305.2 (MH+).