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1,4-Dioxane hydrochloride → N-(5-((1R,2S)-2-(3,5-Dimethoxybenzylamino)-1-hydroxypropyl)-2-hydroxyphenyl)methanesulfonamide

HRID 218114
Notes
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Reaction equation

HRID 218114 reaction equation
O1CCOCC1.[ClH:7].[CH3:8][O:9][C:10]1[CH:11]=[C:12]([CH:31]=[C:32]([O:34][CH3:35])[CH:33]=1)[CH2:13][NH:14][C@@H:15]([CH3:30])[C@@H:16]([C:18]1[CH:19]=[CH:20][C:21]([OH:29])=[C:22]([NH:24][S:25]([CH3:28])(=[O:27])=[O:26])[CH:23]=1)[OH:17]>O1CCOCC1>[ClH:7].[CH3:8][O:9][C:10]1[CH:11]=[C:12]([CH:31]=[C:32]([O:34][CH3:35])[CH:33]=1)[CH2:13][NH:14][C@@H:15]([CH3:30])[C@@H:16]([C:18]1[CH:19]=[CH:20][C:21]([OH:29])=[C:22]([NH:24][S:25]([CH3:28])(=[O:27])=[O:26])[CH:23]=1)[OH:17]
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

5

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 58280637N-(5-((1R,2S)-2-(3,5-Dimethoxybenzylamino)-1-hydroxypropyl)-2-hydroxyphenyl)methanesulfonamide

Product 2

HCID 313Hydrochloric AcidHCID 58280637N-(5-((1R,2S)-2-(3,5-Dimethoxybenzylamino)-1-hydroxypropyl)-2-hydroxyphenyl)methanesulfonamideYield 55%

Reagents, catalysts & solvents 1

HCID 31275
1,4-Dioxane
Solvent

Procedure

4N Hydrogen chloride dioxane solution (0.04 mL) was added to the dioxane solution (1 mL) of the obtained amine (4) (47 mg, 0.11 mmol), and the mixture was freeze-dried, to give hydrochloric acid salt of the amine (4) as white solid (27 mg, yield: 55%).

Workup

  1. customthe mixture was freeze-dried

Sources & evidence

ORD record
ord-74b35d516e144b2cb5352ac44c27309c
Source dataset
uspto-grants-2012_06
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US08198330B2

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes