Hydrogen Bromide → 1-(5-Chloro-2-hydroxyphenyl)piperazine dihydrobromide

Reaction equation

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:14]C)=[C:6]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[CH:7]=1.[BrH:16]>>[BrH:16].[BrH:16].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:14])=[C:6]([N:8]2[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]2)[CH:7]=1

Participants

Reactant 2

HCID 260Hydrogen Bromide

HCID 2735754HCID 2735754, compound

Product 1

HCID 234479081-(5-Chloro-2-hydroxyphenyl)piperazine dihydrobromide

Procedure

A suspension of 5.5 g of 1-(5-chloro-2-methoxyphenyl)piperazine in 40 mL of 62% hydrobromic acid was stirred at reflux for 30 hours. After cooling to room temperature the mixture was filtered by suction and the solid was washed on the funnel with acetone affording 6.02 g of the title compound. M.p.>270° C. (ethanol).

Workup

temperatureat reflux for 30 hours
filtrationwas filtered by suction
washthe solid was washed on the funnel with acetone affording 6.02 g of the title compound

Sources & evidence

ORD record: ord-b5b8d4754fe64f44b7a713d3becbb443
Source dataset: uspto-grants-2002_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06403594B1

Reaction notes

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