Trifluoroacetic acid → 4'-Formylbenzo-15-crown-5

HRID 21885

Reaction equation

HRID 21885 reaction equation
[CH2:1]1[O:19][CH2:18][CH2:17][O:16][CH2:15][CH2:14][O:13][C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[O:6][CH2:5][CH2:4][O:3][CH2:2]1.FC(F)(F)[C:22](O)=[O:23]>>[CH2:1]1[O:19][CH2:18][CH2:17][O:16][CH2:15][CH2:14][O:13][C:12]2[CH:11]=[C:10]([CH:22]=[O:23])[CH:9]=[CH:8][C:7]=2[O:6][CH2:5][CH2:4][O:3][CH2:2]1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 841971,4,7,10,13-Benzopentaoxacyclopentadecin, 2,3,5,6,8,9,11,12-octahydro-

Product 1

HCID 3242434'-Formylbenzo-15-crown-5

Procedure

A solution of hexamethylenetretramine (1.87 mmol, 0.27 g) in trifluoroacetic acid (1.4 cm3) was added to benzo 15-crown-5 ether (1.87 mmol, 0.5 g) under nitrogen; the mixture was heated to reflux for 12 hours.

Workup

  1. temperaturethe mixture was heated
  2. temperatureto reflux for 12 hours

Sources & evidence

ORD record
ord-0aba0da7a8164d719a0f863898cfe358
Source dataset
uspto-grants-1995_06
Patent number
US05425878

Linked notes

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