Thionyl Chloride → 1-(4-Methoxyphenyl)-2,2-dimethylcyclopropanecarbonyl chloride
Reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([C:14]([OH:16])=O)[CH2:11][C:10]2([CH3:13])[CH3:12])=[CH:5][CH:4]=1.S(Cl)([Cl:19])=O>CN(C=O)C>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([C:14]([Cl:19])=[O:16])[CH2:11][C:10]2([CH3:13])[CH3:12])=[CH:5][CH:4]=1Participants
4
Procedure
A mixture of 1-(4-methoxyphenyl)-2,2-dimethylcyclopropanecarboxylic acid (44 mg, 0.20 mmol), thionyl chloride (44 μL, 0.60 mmol) and DMF (1 drop) was stirred at room temperature for 30 minutes. The mixture was concentrated and the resultant acid chloride was used without further purification.
Workup
- concentrationThe mixture was concentrated
- customthe resultant acid chloride was used without further purification
Sources & evidence
- ORD record
- ord-b9be44101d3b49a3b6ab3ddfdd29b7d3
- Source dataset
- uspto-grants-2012_12
- Patent number
- US08324207B2
Reaction notes
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