Cyclobutylamine → N-(cyclobutyl)-3-[(2-fluoro-4-iodophenyl)amino]isonicotinamide

HRID 218927

Reaction equation

HRID 218927 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:18]=[N:17][CH:16]=[CH:15][C:11]=1[C:12]([OH:14])=O.[CH:19]1([NH2:23])[CH2:22][CH2:21][CH2:20]1>>[CH:19]1([NH:23][C:12](=[O:14])[C:11]2[CH:15]=[CH:16][N:17]=[CH:18][C:10]=2[NH:9][C:3]2[CH:4]=[CH:5][C:6]([I:8])=[CH:7][C:2]=2[F:1])[CH2:22][CH2:21][CH2:20]1

Participants

3

Reactant 2

HCID 75645CyclobutylamineHCID 590267913-((2-Fluoro-4-iodophenyl)amino)isonicotinic acid2×

Product 1

HCID 11531663N-(cyclobutyl)-3-[(2-fluoro-4-iodophenyl)amino]isonicotinamide

Procedure

N-(cyclobutyl)-3-[(2-fluoro-4-iodophenyl)amino]isonicotinamide was synthesized according to the procedure for General Method 1, outlined above, starting with 0.34 mmol of 3-[(2-fluoro-4-iodophenyl)amino]isonicotinic acid (intermediate 1) and 0.42 mmol of cyclobutylamine. LC/MS [9.86 min; 412 (M+1)]

Workup

  1. customLC/MS [9.86 min; 412 (M+1)]

Sources & evidence

ORD record
ord-71a8fa6fa5ca4b0bb05619c6014d4d38
Source dataset
uspto-grants-2012_06
Patent number
US08198457B2

Linked notes

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