Hydrochloric Acid → 4-Amino-2-chloro-6-ethylpyrimidine-5-carbonitrile
Reaction equation
[ClH:1].[C:2]([N-:4][C:5](=[C:8]([C:11]#[N:12])[C:9]#[N:10])[CH2:6][CH3:7])#[N:3].[Na+]>>[NH2:12][C:11]1[C:8]([C:9]#[N:10])=[C:5]([CH2:6][CH3:7])[N:4]=[C:2]([Cl:1])[N:3]=1Participants
3
Procedure
With stirring, 200 ml of conc. hydrochloric acid are slowly added dropwise to 37.57 g of ca. 80% strength (178.76 mmol) of sodium cyano[1-(dicyanomethylidene)propyl]-azanide such that the reaction temperature does not exceed 30° C. The reaction mixture is then added to ca. 600 ml of ice water and the solid that is formed is isolated by filtering off with suction. After drying, 33.89 g of 4-amino-2-chloro-6-ethylpyrimidine-5-carbonitrile with the melting point 226.5° C. are obtained.
Workup
- customdoes not exceed 30° C
- customthe solid that is formed
- customis isolated
- filtrationby filtering off with suction
- customAfter drying
Sources & evidence
- ORD record
- ord-dd3a7ea4503a4076a039d7a2ea0f3e94
- Source dataset
- uspto-grants-2012_12
- Patent number
- US08329717B2
Reaction notes
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