Imidazole → 5-(t-Butyldimethylsiloxy)-3-pentyne
Reaction equation
[CH2:1]([OH:5])[CH2:2][C:3]#[CH:4].[Si:6](Cl)([C:9]([CH3:12])([CH3:11])[CH3:10])([CH3:8])[CH3:7].N1C=CN=[CH:15]1>CN(C=O)C>[O:5]([CH2:1][C:2]#[C:3][CH2:4][CH3:15])[Si:6]([C:9]([CH3:12])([CH3:11])[CH3:10])([CH3:8])[CH3:7]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of 3-butyn-1-ol (g) (10.0 g) in DMF (80 ml) were added t-butyldimethylsilyl chloride (21.5 g) and imidazol (10.6 g), and the resultant mixture was kept at 35° C. for 7 hours. The reaction mixture was treated in the conventional manner and the obtained crude product was distilled to give the title compound (h).
Workup
- additionThe reaction mixture was treated in the conventional manner
- customthe obtained crude product
- distillationwas distilled
Sources & evidence
- ORD record
- ord-f6de6665a81f41a69e382a42c905148e
- Source dataset
- uspto-grants-1995_06
- Patent number
- US05426115
Reaction notes
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