Isobutyl chloride → 2-(1-benzyl-1H-indole-6-yl)acetic acid

HRID 2199953

Reaction equation

HRID 2199953 reaction equation
C(Cl)C(C)C.[CH2:6]([N:13]1[C:21]2[C:16](=[CH:17][CH:18]=[C:19]([CH2:22][C:23]([OH:25])=[O:24])[CH:20]=2)[CH:15]=[CH:14]1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>>[CH2:6]([N:13]1[C:21]2[C:16](=[CH:17][CH:18]=[C:19]([CH2:22][C:23]([OH:25])=[O:24])[CH:20]=2)[CH:15]=[CH:14]1)[CH:7]([CH3:12])[CH3:8].[CH2:6]([N:13]1[C:21]2[C:16](=[CH:17][CH:18]=[C:19]([CH2:22][C:23]([OH:25])=[O:24])[CH:20]=2)[CH:15]=[CH:14]1)[C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1

Participants

4

Reactant 2

HCID 10554Isobutyl chlorideHCID 544889242-(1-benzyl-1H-indole-6-yl)acetic acid

Product 2

HCID 544889242-(1-benzyl-1H-indole-6-yl)acetic acidHCID 681837802-(1-isobutyl-1H-indole-6-yl)acetic acid

Procedure

The titled compound (10 mg) as a white solid was prepared from the compound [4-6] obtained in the process (6) of Example 4 (100 mg) and isobutyl chloride according to the method of the process (7) of Example 4.

Sources & evidence

ORD record
ord-89fff89f87f048c5aa6c298f4e4dbe3e
Source dataset
uspto-grants-2016_06
Patent number
US09359350B2

Linked notes

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