HuagongsheHuagongshe Chemistry Print Report · For research reference only
Picolinic acid → Diethyl 2-(5-bromopyridin-2-yl)malonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Picolinic acid | HCID 1018 | — |
| Reactant | Diethyl Malonate | HCID 7761 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 5-Bromo-2-iodopyridine | HCID 593690 | — |
| Catalyst | Copper | HCID 23978 | — |
| Catalyst | Copper iodide | HCID 83717 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | Diethyl 2-(5-bromopyridin-2-yl)malonate | HCID 59238270 | — |
Reaction Steps
2-(5-Bromo-pyridin-2-yl)-malonic acid diethyl ester (XXXVI) is prepared by copper-catalyzed reaction with malonic acid diethyl ester. The reaction is typically performed by mixing XXXV with malonic acid diethyl ester, copper iodide, cesium carbonate, and pyridine-2-carboxylic acid in 1,4-dioxane and heating to 70 degrees Celsius for 24 hours under nitrogen atmosphere.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08202866B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-4a0d2e13f2e54af8857cd02a2ed3add9 |
| Source note | uspto-grants-2012_06 |