反应详情

2-(5-Bromo-pyridin-2-yl)-malonic acid diethyl ester (XXXVI) is prepared by copper-catalyzed reaction with malonic acid diethyl ester. The reaction is typically performed by mixing XXXV with malonic acid diethyl ester, copper iodide, cesium carbonate, and pyridine-2-carboxylic acid in 1,4-dioxane and heating to 70 degrees Celsius for 24 hours under nitrogen atmosphere.

1. temperatureheating to 70 degrees Celsius for 24 hours under nitrogen atmosphere