Hydrochloric Acid → (S)-methyl 2-(2-amino-4-methylpentanamido)acetate hydrochloride

HRID 2201716

Reaction equation

HRID 2201716 reaction equation
C(OC([NH:8][C@@H:9]([CH2:18][CH:19]([CH3:21])[CH3:20])[C:10]([NH:12][CH2:13][C:14]([O:16][CH3:17])=[O:15])=[O:11])=O)(C)(C)C.[ClH:22]>O1CCOCC1>[ClH:22].[NH2:8][C@@H:9]([CH2:18][CH:19]([CH3:21])[CH3:20])[C:10]([NH:12][CH2:13][C:14]([O:16][CH3:17])=[O:15])=[O:11]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 6560406methyl 2-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-4-methylpentanamido]acetate

Product 1

HCID 18603049(S)-methyl 2-(2-amino-4-methylpentanamido)acetate hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a solution of (S)-methyl 2-(2-((tert-butoxycarbonyl)amino)-4-methylpentanamido) acetate (3w) in 1,4-dioxane was added a 5M solution of HCl in 1,4-dioxane at room temperature. The reaction was stirred at room temperature for 16 h. The reaction mixture was filtered to afford (S)-methyl 2-(2-amino-4-methylpentanamido)acetate hydrochloride (4w) as the filtered solid.

Workup

  1. filtrationThe reaction mixture was filtered

Sources & evidence

ORD record
ord-2252f31280bf45b8a8a34205320c0bf4
Source dataset
uspto-grants-2016_06
Patent number
US09365498B2

Linked notes

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