Hydrazine hydrate (1:1) → HCID 4164367, compound
Reaction equation
CS[C:3]([NH:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[C:4]([C:7]#[N:8])[C:5]#[N:6].O.[NH2:17][NH2:18]>CCO>[NH2:6][C:5]1[NH:18][N:17]=[C:3]([NH:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[C:4]=1[C:7]#[N:8]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Dissolved 2-((methylthio)(phenylamino)methylene)malononitrile (3.2 g) in EtOH (100 mL) and added hydrazine hydrate (1 eq), then heated to reflux until complete by TLC (absence of starting material, 18 hrs). Poured into ice water and filtered to obtain 5-amino-3-(phenylamino)-1H-pyrazole-4-carbonitrile as a yellow powder.
Workup
- temperatureheated
- temperatureto reflux until complete by TLC (absence of starting material, 18 hrs)
- filtrationfiltered
Sources & evidence
- ORD record
- ord-8e924ff2dc0d49d6875015eca47a8806
- Source dataset
- uspto-grants-2016_06
- Patent number
- US09365556B2
Reaction notes
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