4-(1-tert-butyl-4-methoxy-1H-pyrazolo[4,3-c]pyridin-3-yl)thiophene-2-carboxamide → 4-(4-methoxy-1H-pyrazolo[4,3-c]pyridin-3-yl)-2-Thiophenecarboxamide
Reaction equation
C([N:5]1[C:13]2[CH:12]=[CH:11][N:10]=[C:9]([O:14][CH3:15])[C:8]=2[C:7]([C:16]2[CH:17]=[C:18]([C:21]([NH2:23])=[O:22])[S:19][CH:20]=2)=[N:6]1)(C)(C)C>FC(F)(F)C(O)=O.O>[CH3:15][O:14][C:9]1[C:8]2[C:7]([C:16]3[CH:17]=[C:18]([C:21]([NH2:23])=[O:22])[S:19][CH:20]=3)=[N:6][NH:5][C:13]=2[CH:12]=[CH:11][N:10]=1Participants
4
Procedure
4-(1-tert-Butyl-4-methoxy-1H-pyrazolo[4,3-c]pyridin-3-yl)thiophene-2-carboxamide (150 mg) obtained in Step C of Example 129 was dissolved in a mixed solvent of trifluoroacetic acid (20 mL)/water (2 mL), and the mixture was heated with reflux for 24 hr. The reaction mixture was allowed to be cooled to room temperature, and concentrated under reduced pressure. The residue was extracted with ethyl acetate and saturated aqueous sodium hydrogencarbonate solution, and the organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate, filtered, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate to ethyl acetate) to give the title compound (68.1 mg).