Iodine → HCID 178478341, compound
Reaction equation
[Cl:1][C:2]1[C:7]2[CH:8]=[N:9][NH:10][C:6]=2[CH:5]=[CH:4][N:3]=1.[OH-].[K+].[I:13]I.S([O-])([O-])(=O)=S.[Na+].[Na+]>COCCOC>[Cl:1][C:2]1[C:7]2[C:8]([I:13])=[N:9][NH:10][C:6]=2[CH:5]=[CH:4][N:3]=1Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 75 °C
Procedure
To a mixture of 4-chloro-1H-pyrazolo[4,3-c]pyridine (4.0 g) and potassium hydroxide (4.4 g) in DME (50 mL) was added iodine (13.3 g) at room temperature. The reaction mixture was stirred at 75° C. for 4 hr. The reaction mixture was added to aqueous sodium thiosulfate solution, and the mixture was left stand overnight, and the resulting solid was collected by filtration to give the title compound (6.3 g).
Workup
- waitthe mixture was left stand overnight
- filtrationthe resulting solid was collected by filtration
Sources & evidence
- ORD record
- ord-5e0d89dc4c6544d79511c505d2dcf26b
- Source dataset
- uspto-grants-2016_06
- Patent number
- US09371320B2
Reaction notes
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