Benzyl Bromide → 2-[(3-Acetyl-1-benzyl-pyridin-1-ium-4-yl)methyl]-6-methoxy-tetralin-1-one bromide
Reaction equation
[C:1]([C:4]1[CH:5]=[N:6][CH:7]=[CH:8][C:9]=1[CH2:10][CH:11]1[CH2:20][CH2:19][C:18]2[C:13](=[CH:14][CH:15]=[C:16]([O:21][CH3:22])[CH:17]=2)[C:12]1=[O:23])(=[O:3])[CH3:2].[CH2:24]([Br:31])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>>[Br-:31].[C:1]([C:4]1[CH:5]=[N+:6]([CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH:7]=[CH:8][C:9]=1[CH2:10][CH:11]1[CH2:20][CH2:19][C:18]2[C:13](=[CH:14][CH:15]=[C:16]([O:21][CH3:22])[CH:17]=2)[C:12]1=[O:23])(=[O:3])[CH3:2]Participants
3
Procedure
The title compound 119 is prepared according to the procedure reported in Example 38.1 with compound 103 (67 mg, 0.2 mmol) and benzyl bromide as reactants. White solid. (Yield 34.5 mg, 80%).
Sources & evidence
- ORD record
- ord-f5f7ce2042d84f28ba74695e36e7b4bd
- Source dataset
- uspto-grants-2016_06