Hydrogen Bromide → 2-Bromo-1-(2,5-dimethyloxazol-4-yl)ethanone

HRID 2210319

Reaction equation

HRID 2210319 reaction equation
[CH3:1][C:2]1[O:3][C:4]([CH3:10])=[C:5]([C:7](=[O:9])[CH3:8])[N:6]=1.[BrH:11].BrBr>C(O)(=O)C>[CH3:1][C:2]1[O:3][C:4]([CH3:10])=[C:5]([C:7](=[O:9])[CH2:8][Br:11])[N:6]=1

Participants

5

Reactant 3

HCID 260Hydrogen BromideHCID 24408BromineHCID 147385831-(2,5-Dimethyl-1,3-oxazol-4-yl)ethan-1-one

Product 1

HCID 140762322-Bromo-1-(2,5-dimethyloxazol-4-yl)ethanone

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent3×

Conditions

Temperature
100 °C

Procedure

2.8 g (0.02 mol) of 2,5-Dimethyl-4-acetyl-oxazole are dissolved in 30 ml of glacial acetic acid, and 3 ml of a 35% strength solution of hydrogen bromide in glacial acetic acid are added. The mixture is heated to 100° C. and, over the course of 1 hour, a solution of 3.2 g (0.02 mol) of bromine in 10 ml of glacial acetic acid is added. After a further 2 hours the solvent is removed, and the residue is triturated with 50 ml of ether and filtered off with suction.

Workup

  1. customAfter a further 2 hours the solvent is removed
  2. customthe residue is triturated with 50 ml of ether
  3. filtrationfiltered off with suction

Sources & evidence

ORD record
ord-723e45e462f54b15bf2716eafa575561
Source dataset
uspto-grants-1995_10
Patent number
US05457205

Linked notes

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