1-(Methoxymethyl)-6-phenylthiothymine → 5-Methyl-6-phenyl-2-sulfanylidene-1,2,3,4-tetrahydropyrimidin-4-one

HRID 2210897

Reaction equation

HRID 2210897 reaction equation
COC[N:4]1[C:12]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[C:10]([CH3:11])[C:8](=[O:9])[NH:7][C:5]1=[S:6]>Cl>[C:13]1([C:12]2[NH:4][C:5](=[S:6])[NH:7][C:8](=[O:9])[C:10]=2[CH3:11])[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

Participants

3

Reactant 1

HCID 540163721-(Methoxymethyl)-6-phenylthiothymine

Product 1

HCID 186710275-Methyl-6-phenyl-2-sulfanylidene-1,2,3,4-tetrahydropyrimidin-4-oneYield 28.1%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

To 100 ml of concentrated hydrochloric acid, 17.2 g (62 mmole) of 1-(methoxymethyl)-6-phenylthiothymine was added and allowed to react for 2 hours at 80° C. The reaction mixture was concentrated under reduced pressure and crystallized from ethanol to obtain 3.8 g of the target compound (Yield: 26%).

Workup

  1. customto react for 2 hours at 80° C
  2. concentrationThe reaction mixture was concentrated under reduced pressure
  3. customcrystallized from ethanol

Sources & evidence

ORD record
ord-0369532af2e4431695b46452e0db0fa1
Source dataset
uspto-grants-1995_10
Patent number
US05461060

Linked notes

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