(alpha,alpha,alpha-Trifluoro-4-tolyl)acetic acid → N-{[4-(3,4-Dichlorobenzyl)morpholin-2-yl]methyl}-2-[4-(trifluoromethyl)phenyl]acetamide

HRID 2211993

Reaction equation

HRID 2211993 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[Cl:17])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH2:13])[CH2:7]1.[F:18][C:19]([F:31])([F:30])[C:20]1[CH:25]=[CH:24][C:23]([CH2:26][C:27](O)=[O:28])=[CH:22][CH:21]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[Cl:17])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH:13][C:27](=[O:28])[CH2:26][C:23]2[CH:22]=[CH:21][C:20]([C:19]([F:30])([F:18])[F:31])=[CH:25][CH:24]=2)[CH2:7]1

Participants

3

Reactant 2

HCID 118342(alpha,alpha,alpha-Trifluoro-4-tolyl)acetic acidHCID 10308229[4-(3,4-Dichlorobenzyl)morpholin-2-yl]methylamine

Product 1

HCID 21962841N-{[4-(3,4-Dichlorobenzyl)morpholin-2-yl]methyl}-2-[4-(trifluoromethyl)phenyl]acetamideYield 16.3%

Procedure

Example 14 was prepared in an analogous manner to Example 1 using a mixture of Intermediate 1 (0.055 g) and [4-(trifluoromethyl)phenyl]acetic acid (0.041 g) to give thetitle compound (0.015 g).

Workup

  1. customExample 14 was prepared in an analogous manner to Example 1 using

Sources & evidence

ORD record
ord-d84e619c9e6849a4a23b0af635468afd
Source dataset
uspto-grants-2006_09
Patent number
US07101882B2

Linked notes

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