Hydrochloric Acid → HCID 57422604, compound

Reaction equation

[CH:1]1([C:6]([CH:8]([NH:13]C(=O)OC(C)(C)C)[CH:9]([CH3:12])[CH2:10][CH3:11])=[O:7])[CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:21]>>[Cl-:21].[CH:1]1([C:6](=[O:7])[CH:8]([NH3+:13])[CH:9]([CH3:12])[CH2:10][CH3:11])[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 21952981HCID 21952981, compound

Product 1

HCID 57422604HCID 57422604, compound

Procedure

4 (0.18 g, 0.63 mmol) was dissolved in 2 ml HCl (7 N in dioxane). After completion of the reaction the solvent was removed and the resulting oil was purified by column chromatography on silical gel using a chloroform/methanol/water gradient. The resulting oil was triturated with ether.

Workup

customAfter completion of the reaction the solvent
customwas removed
customthe resulting oil was purified by column chromatography on silical gel
customThe resulting oil was triturated with ether

Sources & evidence

ORD record: ord-a73c945cf85441cbbaeb2ba84ab204bc
Source dataset: uspto-grants-2006_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07109347B2

Reaction notes

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