Dichloromethane → (2R,4R)-Methyl 4-methoxypyrrolidine-2-carboxylate
Reaction equation
[CH3:1][O:2][C:3]([C@H:5]1[CH2:9][C@@H:8]([O:10][CH3:11])[CH2:7][N:6]1C(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)=[O:4].C(Cl)Cl.C(O)(C(F)(F)F)=O>O>[CH3:1][O:2][C:3]([C@H:5]1[CH2:9][C@@H:8]([O:10][CH3:11])[CH2:7][NH:6]1)=[O:4]Participants
5
Procedure
To a flask containing 3 (4.67 g, 11.6 mmol) was added a solution of CH2Cl2 (27 mL), water (0.3 mL), and TFA (3.0 mL, 38.9 mmol). The solution was stirred at RT for 3 h before concentrating under reduced pressure to reveal impure 4. MS: APCI (AP+): 160.1 (M)+.
Workup
- concentrationbefore concentrating under reduced pressure
Sources & evidence
- ORD record
- ord-8c4124d1caca49cf93d0da5f5bca4c9e
- Source dataset
- uspto-grants-2008_08
- Patent number
- US07407972B2
Reaction notes
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