1-Methyl-3-aminopyrazole → HCID 11652897, compound
Reaction equation
[Al](C)(C)C.C(O[C:8]([C:10]1[C:15]([NH:16][C:17]2[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=2)=[CH:14][CH:13]=[C:12]([CH:23]2[CH2:25][CH2:24]2)[N:11]=1)=[O:9])C.[NH2:26][C:27]1[CH:31]=[CH:30][N:29]([CH3:32])[N:28]=1>>[CH3:32][N:29]1[CH:30]=[CH:31][C:27]([NH:26][C:8]([C:10]2[C:15]([NH:16][C:17]3[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=3)=[CH:14][CH:13]=[C:12]([CH:23]3[CH2:24][CH2:25]3)[N:11]=2)=[O:9])=[N:28]1Participants
4
Procedure
The Al(Me)3-catalyzed reaction of 6-Cyclopropyl-3-(pyridin-3-ylamino)-pyridine-2-carboxylic acid ethyl ester and 3-Amino-1-methylpyrazole in accordance with the general method of Example 78, step 2 yielded the title compound as a light yellow cristalline solid, MS (ISP): m/e=335.4 (M+H+).
Sources & evidence
- ORD record
- ord-3ce30fe6d6a4417d92c15947d4d9d9fb
- Source dataset