(2R)-5'-bromo-3'H-spiro[4-azabicyclo[2.2.2]octane-2,2'-furo[2,3-b]pyridine] → HCID 10404519, compound

HRID 2220132

Reaction equation

HRID 2220132 reaction equation
Br[C:2]1[CH:3]=[C:4]2[CH2:10][C@:9]3([CH:15]4[CH2:16][CH2:17][N:12]([CH2:13][CH2:14]4)[CH2:11]3)[O:8][C:5]2=[N:6][CH:7]=1.C([Sn](CCCC)(CCCC)[C:23]1[C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][C:26]=2[O:25][CH:24]=1)CCC>>[O:25]1[C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=2[C:23]([C:2]2[CH:3]=[C:4]3[CH2:10][C@:9]4([CH:15]5[CH2:16][CH2:17][N:12]([CH2:13][CH2:14]5)[CH2:11]4)[O:8][C:5]3=[N:6][CH:7]=2)=[CH:24]1

Participants

3

Reactant 2

HCID 54506690(2R)-5'-bromo-3'H-spiro[4-azabicyclo[2.2.2]octane-2,2'-furo[2,3-b]pyridine]HCID 686157723-Tri-n-butylstannylbenzofuran

Product 1

HCID 10404519HCID 10404519, compound

Procedure

Prepared by a method analogous to that described for the preparation of Example 4 from (2′R)-5′-bromospiro[1-azabicyclo[2.2.2]octane-3,2′(3′H)-furo[2,3-b]pyridine] and 3-tri-n-butylstannylbenzofuran. The title compound was obtained as a colourless solid; m/e 333 (MH+).

Workup

  1. customPrepared by a method analogous to

Sources & evidence

ORD record
ord-d313a48f61d64c59a329a8ec918a6b31
Source dataset
uspto-grants-2008_08
Patent number
US07417049B2

Linked notes

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