Diethylamine → (2-Bromo-benzyl)-diethyl-amine
Reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8]Br.[CH2:10]([NH:12][CH2:13][CH3:14])[CH3:11]>C1(C)C=CC=CC=1>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][N:12]([CH2:13][CH3:14])[CH2:10][CH3:11]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To 1-Bromo-2-bromomethyl-benzene (2.17 g, 0.008 mmol) in toluene (15 mL) was added diethylamine (3.05 mL) and the mixture was stirred at room temperature for 14 hours. The reaction mixture was filtered and concentrated to give Example 229A as an oil.
Workup
- filtrationThe reaction mixture was filtered
- concentrationconcentrated
Sources & evidence
- ORD record
- ord-ca758fde160a49c097dfedcef981117c
- Source dataset
- uspto-grants-2008_08
- Patent number
- US07417040B2
Reaction notes
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