Ammonium Hydroxide → 4-Bromo-2-fluorobenzenesulphonamide
Reaction equation
[OH-].[NH4+:2].[Br:3][C:4]1[CH:9]=[CH:8][C:7]([S:10](Cl)(=[O:12])=[O:11])=[C:6]([F:14])[CH:5]=1>ClCCl>[Br:3][C:4]1[CH:9]=[CH:8][C:7]([S:10]([NH2:2])(=[O:12])=[O:11])=[C:6]([F:14])[CH:5]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a ammonium hydroxide (28%, 80 ml) was added a solution of 4-bromo-2-fluorobenzenesulfonyl chloride (10 g) in dichloromethane (80 ml) dropwise for 1 hour at approximately 0° C. The reaction mixture was stirred vigorously for an additional 2 hours at the same temperature. The phases were separated. The aqueous phase was washed with dichloromethane. The combined organic extracts were washed with brine, dried over sodium sulfate and evaporated to give 4-bromo-2-fluorobenzenesulfonamide (8.0 g).
Workup
- customThe phases were separated
- washThe aqueous phase was washed with dichloromethane
- washThe combined organic extracts were washed with brine
- dry with materialdried over sodium sulfate
- customevaporated
Sources & evidence
- ORD record
- ord-811634a4ef184929b379d0bad9fb230e
- Source dataset
- uspto-grants-2008_08
- Patent number
- US07417060B2
Reaction notes
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