[OH-].[Na+].[CH2:3]([O:10][C:11]1[CH:16]=[CH:15][C:14]([C@@H:17]([OH:27])[C@@H:18]([NH:20]C(=O)C(F)(F)F)[CH3:19])=[CH:13][C:12]=1[NH:28][S:29]([CH3:32])(=[O:31])=[O:30])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.Cl>CO>[NH2:20][C@@H:18]([CH3:19])[C@@H:17]([C:14]1[CH:15]=[CH:16][C:11]([O:10][CH2:3][C:4]2[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=2)=[C:12]([NH:28][S:29]([CH3:32])(=[O:31])=[O:30])[CH:13]=1)[OH:27]A 5 mol/L aqueous solution of sodium hydroxide (6.3 mL) was added to a solution of N-[(1S,2R)-2-(4-benzyloxy-3-methanesulfonylaminophenyl)-2-hydroxy-1-methylethyl]-2,2,2-trifluoroacetamide (5.5 g) in methanol (100 mL) at room temperature, and the mixture was heated under reflux for 5.5 hrs. After being cooled to room temperature, 2 mol/L hydrochloric acid (15.7 mL) was added to the mixture. The solvent was evaporated under reduced pressure, and the residue was purified by aminopropyl silica gel column chromatography (eluent: ethanol) to afford the title compound (35 g).
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