Hydrochloric Acid → HCID 57422604, compound

Reaction equation

[CH:1]1([C:6]([CH:8]([NH:13]C(=O)OC(C)(C)C)[CH:9]([CH3:12])[CH2:10][CH3:11])=[O:7])[CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:21]>>[Cl-:21].[CH:1]1([C:6](=[O:7])[CH:8]([NH3+:13])[CH:9]([CH3:12])[CH2:10][CH3:11])[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 21952981HCID 21952981, compound

Product 1

HCID 57422604HCID 57422604, compound

Procedure

4 (0.18 g, 0.63 mmol) was dissolved in 2 ml HCl (7 N in dioxane). After completion of the reaction the solvent was removed and the resulting oil was purified by column chromatography on silical gel using a chloroform/methanol/water gradient. The resulting oil was triturated with ether.

Workup

customAfter completion of the reaction the solvent
customwas removed
customthe resulting oil was purified by column chromatography on silical gel
customThe resulting oil was triturated with ether

Sources & evidence

ORD record: ord-5f226638af4a4721ae8f6021d80ee866
Source dataset: uspto-grants-2008_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07368421B2

Reaction notes

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