Ethyl Acrylate → ethyl (1H-1,2,3-triazol-1-yl)propanoate
Reaction equation
[NH:1]1[CH:5]=[CH:4][N:3]=[N:2]1.[C:6]([O:10][CH2:11][CH3:12])(=[O:9])[CH:7]=[CH2:8]>N1C=CC=CC=1>[N:1]1([CH:7]([CH3:8])[C:6]([O:10][CH2:11][CH3:12])=[O:9])[CH:5]=[CH:4][N:3]=[N:2]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 90 °C
Procedure
A mixture of 1,2,3-triazole (5 g, 72.4 mmol) and ethyl acrylate (7.8 ml, 72.4 mmol) containing pyridine (50 drops) was heated at 90° C. for 4 hours. After cooling, the volatiles were removed under vacuum and the residue was purified by column chromatography eluting with methylene chloride/ether to give ethyl (1H-1,2,3-triazol-1-yl)propanoate (8.96 g, 73%).
Workup
- temperatureAfter cooling
- customthe volatiles were removed under vacuum
- customthe residue was purified by column chromatography
- washeluting with methylene chloride/ether
Sources & evidence
- ORD record
- ord-9cff62d587e04cbab690f0b93bcf2acd
- Source dataset
- uspto-grants-2008_05
- Patent number
- US07371765B2
Reaction notes
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