Diphosgene → HCID 15765403, compound
Reaction equation
[NH2:1][C:2]1[C:10]2[O:9][C:8]([CH3:12])([CH3:11])[O:7][C:6]=2[C:5]([Cl:13])=[CH:4][C:3]=1[F:14].Cl[C:16](OC(Cl)(Cl)Cl)=[O:17]>C1(C)C=CC=CC=1>[Cl:13][C:5]1[C:6]2[O:7][C:8]([CH3:11])([CH3:12])[O:9][C:10]=2[C:2]([N:1]=[C:16]=[O:17])=[C:3]([F:14])[CH:4]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of 1.5 g (0.0069 mole) of 4-amino-7-chloro-2,2-dimethyl-5-fluoro-1,3-benzodioxole in 50 mL of toluene was added slowly 0.41 mL (0.0035 mole) of trichloromethyl chloroformate. This mixture was stirred at ambient temperature for one hour and then was heated at reflux for approximately 16 hours. At the conclusion of this period the solvent was evaporated from the reaction mixture under reduced pressure, leaving 7-chloro-2,2-dimethyl-5-fluoro-1,3-benzodioxol-4-yl isocyanate as a residue which was used in the next step without further purification.