Formic Acid → 3-(3,4-Dimethoxyphenyl)propionic acid

HRID 2227018

Reaction equation

HRID 2227018 reaction equation
C(O)=O.[C:4]1([CH:10]2[O:15]C(=O)CC(=O)[O:11]2)C=CC=CC=1.[CH:18](=O)[C:19]1[CH:28]=[CH:27][C:24]([O:25][CH3:26])=[C:21]([O:22][CH3:23])[CH:20]=1>C(N(CC)CC)C>[CH3:23][O:22][C:21]1[CH:20]=[C:19]([CH2:18][CH2:4][C:10]([OH:15])=[O:11])[CH:28]=[CH:27][C:24]=1[O:25][CH3:26]

Participants

5

Reactant 3

HCID 284Formic AcidHCID 8419VeratraldehydeHCID 9338292-Phenyl-1,3-dioxane-4,6-dione

Product 1

HCID 750193-(3,4-Dimethoxyphenyl)propionic acid

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

25 ml of the mixture of formic acid and triethylamine prepared as described in Example 1 were added to a mixture of 4.8 g (0.025 mol) of 2-phenyl-1,3-dioxane-4,6-dione (m.p.: 148° C.) and 4.15 g (0.025 mol) of veratraldehyde. The reaction was carried out according to Example 1.

Sources & evidence

ORD record
ord-53c4755b30c94dd4bdd836cf47741ffb
Source dataset
uspto-grants-1994_09
Patent number
US05350872

Linked notes

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